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This SCP prevents users or roles in any affected account from leaving AWS Organizations, either directly as a command or through the console.
See Related Configuration Items for a Configuration Package to deploy multiple SCPs to an AWS Account.
Configuration template includes a CloudFormation custom resource to deploy into an AWS account.
{
    "Version": "2012-10-17",
    "Statement": [
        {
            "Action": [
                "organizations:LeaveOrganization"
            ],
            "Resource": "*",
            "Effect": "Deny"
        }
    ]
}